Welcome to the the Lab page of Stephen C. Pelsue, Ph.D. at the University of Southern Maine in the Department of Applied Medical Sciences . Research in the lab focuses on understanding the role of autoantibodies in autoimmunity, particularly Systemic Lupus Erythematosus (SLE or Lupus).
- Major research areas in the lab include:
- The role of Ttc7 in B cell development, regulation, & antibody production
- The role of Ttc7 in regulating PI4KIIIα
- The impact of ER stress on B cell function & antibody production
- The impact of microgravity on B cell growth and function
There are over 100 autoimmune diseases and as a group represent the second leading cause of chronic illness in Americans (AARDA). Some well known autoimmune diseases are Lupus, Multiple Sclerosis, Rheumatoid Arthritis, Chron’s Disease, Psoriasis, and Type 1 Diabetes Mellitus. Autoimmune diseases predominantly affect women and as a group are the leading cause of death in women (AARDA). The costs are staggering, both in economic terms as well as in the physical and emotional terms; and the goal of the Pelsue Lab is to better understand the underlying cause of autoimmunity, Lupus in particular, to aid in the development of better diagnosis and treatment for patients suffering from autoimmunity.